Endocrine Abstracts

Background: Primary Hyperparathyroidism (PHPT) is the leading cause of hypercalcaemia. Early diagnosis and management is important to prevent long term complications. National institute of clinical excellence (NICE) published guidelines on diagnosis and management of Primary Hyperparathyroidism and we sought to compare our practice with the NICE guideline (NG 132).Methods: This was a retrospective observational study of ...

Dietary guidelines in the UK and worldwide recommend reducing the quantity of free sugars in the diet. The consumption of foods high in free sugars can lead to postprandial hyperglycaemia and hyperinsulinemia, which have been implicated in the development of metabolic diseases including type 2 diabetes and obesity. Rare sugars (naturally occurring monosaccharides which hardly exist in nature) have been found to suppress the postprandial elevation in blood glucose and improve g...

Objectives: Fracture risk is increased in individuals with diabetes mellitus, but how this is related to bone mineral density (BMD), adiposity, inflammation, disease duration and diabetic complications is less well understood. We aimed to investigate associations between type 1 (T1DM) and type 2 (T2DM) diabetes and incident fracture in a large population study.Methods: UK Biobank is a population study incorporating indiv...

Introduction: FKBP prolyl isomerase 4, encoded by the gene FKBP4, is a member of the FK506-binding protein family and is presumed to be a regulator of the androgen receptor (AR) pathway. Mutations in FKBP4 have been proposed to cause Androgen Insensitivity Syndrome (AIS), with only one case reported in the literature so far.Aim: To report the clinical, biochemical and genetic findings in an infant with 46, XY DSD a homoz...

Background: UCSF Cancer Center is committed to offering all patients information on Advance Directives; however, many patients do not have their wishes well-documented in their EMR. Our clinic has implemented a workflow for introducing advance care planning discussion into treatment teaching sessions. We have begun to share this workflow throughout the cancer center. Many patients in our clinic have metastatic disease and are treated for months to years by our team. It is impo...

Background: Dexamethasone significantly improved outcomes in patients requiring supplementary oxygen and in ventilated patients with COVID-19 in the RECOVERY trial. Consequently, dexamethasone is now routinely used in these patients. However, dysglycaemia is commonly associated with steroid use and is an established risk factor for poorer outcomes in COVID-19. In this study, we aimed to elucidate the effect of dexamethasone use in patients hospitalised with COVID-19 in a real-...

Introduction: Diabetes has been associated with poorer outcomes with COVID-19 infection, but precise predictors of mortality in patients with diabetes remain unclear. We assessed predictors of adverse outcomes in patients hospitalised with COVID-19 in Imperial College Healthcare NHS Trust (ICHNT) hospitals during the first and second waves of COVID-19 to determine if outcomes for patients with diabetes have evolved with new variants and treatments.Method...

The introduction of immune checkpoint inhibitors (ICIs) in clinical management of cancer has had an undeniable impact in management of cancer patients. Currently there are several ICIs are used across Europe including but not limited to, pembrolizumab, atezolizumab, and ipilimumab. Even though their clinical efficacy is reputable, they have the potential of causing serious immunotherapy-related adverse events’ (irADRs) in several organ systems including endocrine organs. ...

Regulators are concerned about the potential for environmental chemicals such as agrochemicals and their metabolites to perturb hormone systems. This has led to recommendations for the testing of potential endocrine disrupting chemicals1. The Steroidogenesis H295R assay is an in vitro cell model used to investigate compound effects on steroid hormone biosynthesis, specifically 17β-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma ce...

Introduction: Minimally invasive surgical treatment of primary hyperparathyroidism (PHPT) requires optimal preoperative localisation imaging. Parathyroid four-dimensional CT (4D-CT) has been reported to provide greater sensitivity than MIBI-SPECT/CT in localizing parathyroid adenomas. We analysed the additional value of 4D-CT in our cohort of PHPT patients.Materials and methods: Patients who attended our parathyroid clinic between February 2016 and April...